PYRROLE-CONDENSED MORPHINOID DERIVATIVES

摘要

A compound or a salt or solvate thereof, of formula (I): in which: R<1> is hydrogen, alkenyl or alkyl; R<2> is hydrogen or one or more alkyl groups; R<5> is hydrogen or alkyl; RX is hydrogen or alkyl; or RX together with R3 represent a bond; when RX is hydrogen or alkyl, then Rz is hydrogen or alkyl; and R3 is selected from hydrogen, optionally substituted alkyl, aryl, aryl-alkyl, cycloalkyl and heterocyclyl; or from hydrogen or an optionally substituted alkyl, aryl, aryl-alkyl, cycloalkyl or heterocyclic group linked to the piperidine ring via <C=O, -O-CO-, -O-CO-NH-, -CO-NH-, -NH-CO- or ?SO>2<; and R>4< is selected from hydrogen, alkyl, -CN, -COR>1< and -OR>1< (where R>1< is as defined above) or a -NR>6<R>7< group, where R>6< and R>7< are selected independently from hydrogen and alkyl, or R>6< is -COR>8< where R>8< is hydrogen, alkyl or optionally substituted aryl; aryl-alkyl, cycloalkyl or heterocyclyl; or R>3< and R>4< together form a spiro-cyclyalkyl, spiro-heterocyclyl or an unsaturated spiro-carbocyclyl group; when R>X< together with R>3< represent a bond then: R>4< is a group R>4X< and R>Z< is a group R>3X<; wherein R>3X< and R>4X< are independently selected from hydrogen or optionally substituted alkyl, aryl, aryl-alkyl, cycloalkyl or heterocyclyl; or R>3X< and R>4X< together form an aliphatic or aromatic group, or a heterocyclyl group containing one or two heteroatoms selected form N, S and O; provided that when R>5< is methyl and R>3< and R>4< are both hydrogen, then R>2< is not hydrogen.