发明名称 |
PROCESSES FOR THE PREPARATION OF 5-HYDROXY-3-OXOPENTANOIC ACID DERIVATIVES |
摘要 |
Processes by which 5-hydroxy-3-oxopentanoic acid derivatives useful as intermediates of drugs can be prepared from inexpensive and easily available raw materials under noncryogenic conditions. Specifically, a process for preparing 5-hydroxy-3-oxopentanoic acid derivatives by making lithium amide act on a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative at a temperature of -20 DEG C or above; and another process for preparing 5-hydroxy-3-oxopentanoic acid derivatives by treating a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative with a Grignard reagent and then making lithium amide act on the resulting mixture at a temperature of -20 DEG C or above. |
申请公布号 |
EP1104750(A4) |
申请公布日期 |
2002.04.10 |
申请号 |
EP20000935526 |
申请日期 |
2000.06.02 |
申请人 |
KANEKA CORPORATION |
发明人 |
NISHIYAMA, AKIRA;INOUE, KENJI |
分类号 |
C07C67/343;C07C253/30;C07C255/21;C07D319/06;C12P7/62 |
主分类号 |
C07C67/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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