发明名称 |
RAT CATHEPSIN, DIPEPTIDYL PEPTIDASE I (DPPI): CRYSTAL STRUCTURE, INHIBITORS AND ITS USES |
摘要 |
The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co - complexes. Included in the present invention is a crystal of a dipeptidyl peptidase I (DPPI) and corresponding structural information obtained by X-ra y crystallography from rat and human DPPI. In addition, this invention relates to methods for using structure co-ordinates of DDPI, mutants hereof andco- complexes, to design compounds that bind to the active site or accessory binding sites of DPPI and to design improved inhibitors of DPPI or homologue s of the enzyme.
|
申请公布号 |
CA2422057(A1) |
申请公布日期 |
2002.03.14 |
申请号 |
CA20012422057 |
申请日期 |
2001.09.06 |
申请人 |
PROZYMEX A/S |
发明人 |
TURK, DUSAN;KADZIOLA, ANDERS;LARSEN, SINE;PEDERSEN, JOHN;STERN, IGOR;OLSEN, JOHAN GOTTHARDT;LAURITZEN, CONNIE;PODOBNIK, MARJETKA;DAHL, SOREN WEIS |
分类号 |
A61P11/00;A61P31/00;C12N9/48;C12N15/57;G06F19/16;G06F19/18;(IPC1-7):C12N15/57;C07K1/14;C07K14/435;C12Q1/68 |
主分类号 |
A61P11/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|