Bicyclic heteroaromatic derivatives for the treatment of immune and inflammatorydisorders

摘要

Compounds of formula (1) are described, wherein q is zero or the integer 1, 2 or 3; R which when present may be attached to any available carbon or nitrogen atom of the bicyclic heteroaromatic ring of formula (1) is an atom or group -L<3>(Alk<3>)wL<4>(R<8>)u; X is an O atom or a S(O)m atom or group in which m is zero or the integer 1 or 2 or an NR group; Y is a N atom or a CR<1a >group in which R<1a >is a group R or a group R<1>; R<1 >which may he on any available carbon atom of the bicyclic heteroaromatic ring of formula (1) is a hydrogen atom or a group -Alk<1>L<1>CyAlk<2>L<2>D; provided that at least one but not both of R<1 >and R<1a >is the group -Alk<1>L<1>CyAlk<2>L<2>D. The compounds are potent inhibitors of the interaction between CCR-3 and it chemokine ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders in which inhibition of this interaction can have a beneficial effect.