| 摘要 |
The present invention provides a method for the treatment of infllammation a nd pain in a mammal requiring such treat- ment, comprising administering to said mammal an anti-inflammatory and analgesically effective amount of an indomethacin salt of a divalent metal capable of forming a stable complex with indomethacin, or of a pharmaceutical composition comprising said indomethacin salt together with a pharmaceutically acceptable carrier, diluent and/or excipient. The present invention also provides a process for the preparation of an indomethacin salt of a divalent metal capable of forming a stable complex with in- domethacin comprising forming a solution by dissolving indomethacin and a sa lt of said divalent metal in a tertiary amide or cyc- lic tertiary amide, adding a C1-4 alkanol or C3-6 ketone to the solution to precipitate the indomethacin metal salt and separat- ing the indomethacin metal salt precipitate from the solution. The present invention still further provides a pharmaceutical composition fog alleviating inflammation and pain comprising an anti- inflammatory and analgesically effective amount of salts of indomethacin produced by the process of the invention together with a pharmaceutically acceptable carrier, diluent and/or excipient.
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