| 摘要 |
<i>Helicobacter pylori</i> can be manipulated at a genetic level to prevent the synthesis of auto-reactive LPS, without destroying the physical integrity or function of the bacterial outer membrane. The bacterium is particularly useful for preparing cellular vaccines which do not induce antibodies which cross-react with self epitopes. Cellular <i>H.pylori</i> vaccines are provided which comprise mutant <i>H.pylori</i> which either does not express LPS or, preferably, expresses a mutant form of LPS. |
