发明名称 |
HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP |
摘要 |
Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, or substituents R9-R12 are independently hydrogen, or substituents provided that at least one of R9-12 is not hydrogen; G is a monocyclic heteroaryl: X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
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申请公布号 |
WO0034261(A3) |
申请公布日期 |
2002.01.31 |
申请号 |
WO1999US28916 |
申请日期 |
1999.12.06 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
BLOOM, JONATHAN, DAVID;CURRAN, KEVIN, JOSEPH;DIGRANDI, MARTIN, JOSEPH;DUSHIN, RUSSELL, GEORGE;JONES, THOMAS, RICHARD;LANG, STANLEY, ALBERT;ROSS, ADMA, ANTONIA;TEREFENKO, EUGENE, ANTHONY;O'HARA, BRYAN, MARK |
分类号 |
C07D277/20;A61K31/341;A61K31/421;A61K31/426;A61K31/433;A61P31/12;C07C335/20;C07C335/22;C07D233/90;C07D263/34;C07D277/56;C07D285/06;C07D307/68;(IPC1-7):C07D307/68;A61K31/416;A61P31/22 |
主分类号 |
C07D277/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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