NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN AND DNA THEREOF

摘要

A novel G protein-coupled receptor protein containing an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or its salt; a polynucleotide encoding the same; utilization thereof in drugs, etc. The above-described G protein-coupled receptor protein, a peptide fragment thereof or a salt of the same and the polynucleotide (a DNA, an RNA, a derivative thereof, etc.) encoding this receptor protein or a peptide fragment thereof are usable in, for example: (1) determining a ligand (an agonist); (2) acquiring an antibody and an antiserum; (3) constructing a recombinant receptor protein expression system; (4) developing a receptor-bonded assay system and screening a candidate compound for a drug with the use of the above expression system; (5) designing a drug based on comparison with a ligand receptor having a similar structure; (6) reagents for preparing a probe for gene therapy and a PCR primer; (7) constructing a transgenic animal; and (8) drugs such as gene preventives and remedies.