发明名称 |
SUCCINOYLAMINO CARBOCYCLES AND HETEROCYCLES AS INHIBITORS OF A beta PROTEIN PRODUCTION |
摘要 |
This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A beta -peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome.
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申请公布号 |
WO0160826(A3) |
申请公布日期 |
2002.01.17 |
申请号 |
WO2001US05236 |
申请日期 |
2001.02.16 |
申请人 |
DUPONT PHARMACEUTICALS COMPANY |
发明人 |
OLSON, RICHARD, E.;MADUSKUIE, THOMAS, P.;THOMPSON, LORIN, ANDREW;TEBBEN, ANDREW, J.;WANG, NENGHUI;DENG, WEI;LIU, HONG |
分类号 |
C07D243/10;A61K31/225;A61K31/55;A61K31/551;A61K31/5517;A61P25/28;C07C233/09;C07D243/24;C07D401/06;C07D471/04;C07D471/06;C07D471/08;C07D487/04;C07D487/06;(IPC1-7):C07D487/04 |
主分类号 |
C07D243/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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