发明名称 ESTER DERIVATIVES
摘要 Compounds of the general formula (¦), which exhibit selective muscarinic M3 receptor antagonism, little have side effects, and are suitable for administration by inhalation and useful as therapeutic agents for respiratory system diseases or the like: (¦) wherein A is a group of the general formula (a0) or (b0): (a0) (b0) Ar is aryl or heteroaryl, any of which may be substituted; B<1> and B<2> are each an aliphatic hydrocarbon group; R<1> is fluorinated cycloalkyl; R<2>, R<3> and R<4> are each lower alkyl, or a single bond or alkylene, any of which is bonded to B<1>, or alternatively R<2> and R<3> may be united to form alkylene; R<5> and R<7> are each hydrogen, lower alkyl, or a single bond or alkylene, any of which is bonded to B<2>; R<6> is hydrogen, lower alkyl, or N(R<8>)R<9>; and X<-> is an anion.
申请公布号 WO0204402(A1) 申请公布日期 2002.01.17
申请号 WO2001JP05987 申请日期 2001.07.10
申请人 发明人 OGINO, YOSHIO;KURIHARA, HIDEKI;MATSUDA, KENJI;NUMAZAWA, TOMOSHIGE;OTAKE, NORIKAZU;NOGUCHI, KAZUHITO
分类号 A61P11/00;A61P11/06;A61P27/16;A61P43/00;C07C219/10;C07C219/14;C07D205/04;C07D207/08;C07D207/12;C07D209/52;C07D211/22;C07D211/42;C07D211/46;C07D211/70;C07D239/06;C07D451/02;C07D451/06;C07D471/08;C07D471/10;C07D487/10;C07D498/10;(IPC1-7):C07C219/10;C07C219/22;C07C219/24;C07C251/08;C07C251/18;C07D405/12;C07D221/24;C07D295/125;A61K31/452;A61K31/439;A61K31/435;A61K31/440;A61K31/403;A61K31/222;A61K31/395;A61K31/40;A61K31/538;A61K31/438;A61K31/407;A61K31/397;A61K31/55 主分类号 A61P11/00
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