CALIXARENES AND CALIXARENE-BASED SENSORS

摘要

A calixarene dimer of the general formula (I-G), comprising a first calixarene moiety I and a second calixarene moiety G, wherein: L is [ - CH2 -] or [ -O-CH2-O- ] and is the same or different between each aryl group; R<5> is H, NO2, halogen, or C1 - C10 aliphatic hydrocarbyl group, C6 - C20 aryl group, C6 - C20 hydrocarbylaryl group, any of which is optionally substituted by one or more halo or oxo groups or interrupted by one or more oxo or amide groups, and R<5> is the same or different on each aryl group; R<1> comprises a carboxy group which is or is not protonated or protected; two groups out of R<2>, R<3> and R<4> are H; the one group out of R<2>, R<3> and R<4> not being H comprises at least one atom of one or more of O and S, the said at least one atom being capable of causing the calixarene to be adsorbed onto the surface of the substrate; and the one group out of R<2>, R<3> and R<4> not being H being conjugated to the second calixarene moiety G. The calixarene dimers may be incorporated into sensors. Methods of making the calixarene dimers are disclosed.