发明名称 |
USE OF INHIBITORS OF PLACENTAL GROWTH FACTOR FOR THE TREATMENT OF PATHOLOGICAL ANGIOGENESIS, PATHOLOGICAL ARTERIOGENESIS, INFLAMMATION, TUMOUR FORMATION AND/OR VASCULAR LEAKAGE |
摘要 |
The present invention relates to the field of pathological angiogenesis and arteriogenesis. In particular, the invention describes a stress induced phenotype in a transgenic mouse (PIGF-/-) which does not produce Placental Growth Factor (PIGF) and which demonstrates an impaired vascular endothelial growth factor (VEGF)-dependent response. It is revealed that PIGF-deficiency has a negative influence on diverse pathological processes of angiogenesis, arteriogenesis and vascular leakage comprising ischemic retinopathy, tumour formation, pulmonary hypertension, vascular leakage (oedema formation) and inflammatory disorders. The invention thus relates to molecules which can inhibit the binding of PIGF to its receptor (VEGFR-1), such as monoclonal antibodies and tetrameric peptides. The invention further relates to the use of these molecules to treat the latter pathological processes.
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申请公布号 |
CA2407858(A1) |
申请公布日期 |
2001.11.15 |
申请号 |
CA20012407858 |
申请日期 |
2001.05.10 |
申请人 |
D. COLLEN RESEARCH FOUNDATION VZW;VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
DE FALCO, SANDRO;MENOTTI, RUVO;COLLEN, DESIRE;CARMELIET, PETER |
分类号 |
A61K38/00;A61K38/07;C07K1/04;C07K16/22;(IPC1-7):C07K16/22;C12N9/00;A61P35/00;C12N15/11;A61P9/12;A61P9/14;C07K16/28;A61K39/395;G01N33/50;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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