N,n-disubstituted piperazine derivatives

摘要

The invention comprises compounds of the general formula: (wherein R1 and R2, which may be the same or different, each represents a phenyl or halophenyl group, Y represents an -S- or -SO2- radical and R3 represents an ethyl, benzyl or nuclear C1- 4- alkyl substituted benzyl group) and non-toxic acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by reacting a compound of the general formula: with R3X (wherein X represents a halogen atom), optionally followed by acid addition salt formation. Monosubstituted piperazines of the second general formula above may be prepared by condensing the appropriate diphenylmethyl mercaptan with an N-(2-haloethyl)-piperazine or an appropriate diphenylmethyl-(2-haloethyl) sulphide with piperazine, optionally followed in either case by oxidation to the sulphone. The sulphones can alternatively be prepared by condensing the sodium salt of the appropriate diphenylmethylsulphinic acid with an N-(2-haloethyl)-piperazine. The compounds of the invention have an antiulcerous action, and may be administered in the form of pharmaceutical preparations containing them together with a non-toxic inert carrier.