| 摘要 |
Novel human ubiquitin conjugating enzyme-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ubiquitin conjugating enzyme-like proteins, the invention further provides isolated ubiquitin conjugating enzyme-like fusion proteins, antigenic peptides, and anti-ubiquitin conjugating enzyme-like antibodies. The invention also provides ubiquitin conjugating enzyme-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a ubiquitin conjugating enzyme-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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