发明名称 |
flt3-L mutants and method of use |
摘要 |
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.
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申请公布号 |
US6291661(B1) |
申请公布日期 |
2001.09.18 |
申请号 |
US19980109100 |
申请日期 |
1998.07.02 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
GRADDIS THOMAS J.;MCGREW JEFFREY T. |
分类号 |
A61K38/00;A61K39/39;C07K14/52;C12N5/0784;C12N15/10;C12N15/19;(IPC1-7):C07H21/04;C07K19/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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