| 发明名称 |
CD40-BINDING APC-ACTIVATING MOLECULES |
| 摘要 |
Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells ("APCs"), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
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| 申请公布号 |
WO0156603(A1) |
申请公布日期 |
2001.08.09 |
| 申请号 |
WO2001US03378 |
申请日期 |
2001.02.01 |
| 申请人 |
TANOX, INC. |
发明人 |
THOMAS, DAVID;DE BOER, MARK;RES, PIETER, C., J., M.;SIMONS, PETER, J. |
| 分类号 |
C12P21/08;A61K38/00;A61K39/395;A61P35/00;A61P37/02;C07K16/28;C12N5/10;C12N15/12;C12N15/13;C12R1/91;(IPC1-7):A61K39/395;C07K16/00;C12N5/12;C12N15/00;C12N15/11;C12N15/63 |
主分类号 |
C12P21/08 |
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