发明名称 |
METHOD FOR MAKING QUINOLONE CARBOXYLIC ACIDS OR NAPHTHYRIDINE CARBOXYLIC ACIDS IN FREE BASE FORM |
摘要 |
<p>The present invention provides a method of making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form, the method comprising dissolving a quinolone carboxylic acid salt or naphthyridine carboxylic acid salt in a solvent system to form a solution; combining the solution containing the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt with a calcium salt in an amount in the range of about 0.01% to about 5.0% by weight of the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt and a base, the combination resulting in the formation of a precipitate; and collecting the precipitate. Also provided is a solid bulk pharmaceutical chemical composition which is the product resulting from the precipitation.</p> |
申请公布号 |
GR3035818(T3) |
申请公布日期 |
2001.07.31 |
申请号 |
GR20010400666T |
申请日期 |
2001.04.30 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
DOZEMAN, GARY, JAY;PORTER, KENNETH, THOMAS;WEMPLE, JAMES, NORTON |
分类号 |
C07D401/04;A61K31/47;A61P31/04;C07D215/56;C07D471/04;(IPC1-7):C07D215/56;A61K31/435 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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