发明名称 |
Attenuated microorganism strains and their uses |
摘要 |
This application relates to the use of attenuated prokaryotic miccrooganism strains (such as Salmonella) expressing nucleic acid encoding HPV proteins as vaccines against HPV infection and he associated increased risk of cancer. In particular, the work shows that it is possible to assemble VLPs in a prokaryotic organism and that nasal immunization of mice with the strains HPV-specific conformationally dependent and neutralizing antibodies in serum and genital secretions. The experiments described herein show that it is also possible to assemble chimeric VLPs of a HPV including a fusion partner and that tumor protection can be induced.
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申请公布号 |
US6251406(B1) |
申请公布日期 |
2001.06.26 |
申请号 |
US19990413807 |
申请日期 |
1999.10.07 |
申请人 |
BTG INTERNATIONAL LIMITED |
发明人 |
HAEFLIGER DENISE N.;KRAEHENBUHL JEAN-PIERRE |
分类号 |
G01N33/569;A61K39/00;A61K39/12;A61P31/12;A61P31/20;A61P35/00;C07K14/025;C12N1/21;C12N15/09;C12N15/37;C12N15/74;C12R1/42;G01N33/574;(IPC1-7):A61K39/112 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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