DERIVATIVES OF PIPERIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE SUBSTANCES

摘要

organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of piperidine of the formula (I) where R1 is aryl heterocyclyl; R2 is phenyl, naphthyl, acenaphthyl, cyclohexyl, pyridyl, pyrimidinyl, pyrazinyl, oxopyridinyl, diazinyl, triazolyl, thienyl, oxazolyl, oxadiazolyl, thiazolyl, pyrrolyl or furyl that can be substituted with halogen atom, hydroxy-group, cyano-group, CF3, alkyl; R3 is H, hydroxy-group, alkoxy-group, alkenylhydroxy-group; R4 is H, alkyl, alkenyl, alkoxy-group, benzyl, oxo-group; Q is ethylene or absent; X is bond, oxygen, sulfur atom; W is oxygen or sulfur atom; Z is alkylene, alkenylene, -O, -S; n = 1; m = 0 or 1. Compounds of the formula (I) show inhibitory activity with respect to rennin activity and can be used in medicine. Invention describes intermediate compounds of the formula (II) where R1 means protective group and other symbols have values indicated for compounds of the formula (I). EFFECT: new compounds indicated above, valuable medicinal properties. 24 cl, 1 tbl, 159 ex