A screening method to identify agents that selectively inhibit Hepatitis C virus replication in viruses that contain an ISDR region

摘要

The invention relates to a method for identifying antiviral agents which selectively interfere with viral proteins that override interferon-induced cellular defence mechanisms against viral infection. Screening assays are disclosed which identify agents which selectively inhibit the interaction between viral proteins containing an interferon sensitivity determining region, and interferon-induced PKR protein kinase.