METHODS AND COMPOSITIONS FOR TREATMENT OF TRAUMATIC BRAIN INJURY

摘要

The present invention provides methods and compositions for administration of nerve growth factor into subjects in whom the central nervous system has been damaged by trauma. The invention relates to formulations of nerve growth factor and their use in prevention of cognitive, motor or sensory deficits associated with traumatic injury of the brain or spinal cord. The invention further provides methods for treating such injuries comprising the administration of nerve growth factor formulations into the injured central nervous system. The present invention is based on the identification of novel optimal nerve growth factor dosages and treatment schedules to be used in the treatment of brain injured patients. In embodiments of the invention, nerve growth factor formulations are administered to subjects where the nervous system has been damaged by trauma to enhance the survival, growth or repair of neuronal cells.