| 发明名称 |
DISULFIDE CONJUGATED CELL TOXINS AND METHODS OF MAKING AND USING THEM |
| 摘要 |
The invention pertains to the discovery of novel disulfide linked cell toxin s which can ablate NK-1 receptor expressing cells. These toxins are used as pharmaceutical compositions for the ablation of NK1 receptor expressing cell s and comprise a substance P (SP)-Pseudomononas exotoxin disulfide linked conjugate. The invention also includes methods of making and using these toxins and pharmaceutical compositions.
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| 申请公布号 |
CA2388165(A1) |
申请公布日期 |
2001.05.03 |
| 申请号 |
CA20002388165 |
申请日期 |
2000.10.20 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRE |
发明人 |
FITZGERALD, DAVID J.;IADAROLA, MICHAEL J. |
| 分类号 |
A61K38/00;A61K47/48;C07K7/22;C07K14/21;C12N15/31;(IPC1-7):C07K14/21;C07K7/06 |
主分类号 |
A61K38/00 |
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