beta-secretase antibody

摘要

Compositions comprising a novel protease capable of cleaving beta-amyloid precursor protein (APP) on the amino-terminal side of the beta-amyloid peptide therein are provided. The protease is designated beta-secretase. Reaction systems comprising beta-secretase may be used in screening assays to monitor beta-secretase modulated cleavage of APP and to identify beta-secretase inhibitors, wherein the beta-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of beta-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.