MODEL ANIMAL OF MESANGIAL CELL PROLIFERATIVE NEPHRITIS

摘要

A model animal of mesangial cell proliferative nephritis obtained from a megsin transgenic animal. A transgenic mouse constructed by using a megsin gene exhibits typical symptoms of mesangial cell proliferative nephritis associated by the enlargement of the mesangial base region, the sedimentation of an immune complex and an increase in mesangial cells. This model animal of mesangial cell proliferative nephritis is useful in analyzing the pathological conditions of chronic glomerular diseases and screening remedies therefor.