Neue C13-substituierte Estra-1,3,5(10)-trien-3-yl-sulfamate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

摘要

The invention relates to novel C13-substituted estra-1,3,5(10)-triene-3-yl-sulfamates of general formula (I), in which R1 represents the acyl radical, oxycarbonyl radical, aminocarbonyl radical, sulfonyl radical or aminosulfonyl radical and R15 stands for C2-C5 alkyl, C2-C5 alkenyl or C2-C5-alkinyl. The invention also relates to a method for producing these compounds and to pharmaceutical compositions which contain said compounds. The inventive compounds of general formula (I) inhibit the activity of steroid sulfatases (EC 3.1.6.2) and do not exhibit any oestrogenic action.