| 摘要 |
A carbocyclic oligomer consisting of 2 to 10 units derived from the fumaric acid and/or esters and/or amides thereof as repeating units, of the following formula (I); and the use these oligomer compounds for preparing a pharmaceutical preparation as well of pharmaceutical preparations containing these compounds is disclosed, wherein the groups R1 and R2 are the same or different and are selected from the group consisting of amine groups (-NR3R4) amino acid groups (-NH-CH(COOH)-R6), peptide groups having 2 to 100 amino acids, alkoxy groups (-OR5) and hydroxyl groups, wherein either one of R1 or R2 may be OH, n is an integer between 2 and 10, the groups R3 and R4 are the same or different and are selected from the group consisting of hydrogen, and C1-24-alkyl groups, the group R5 is selected from C1-24-alkyl groups, and the group R6 represents the side chain of a natural or synthetic amino acid. The pharmaceutical preparations containing these compounds are intended for treating an autoimmune disease, for transplantation medicine (host-vs-graft rejection), for treating mitochondrial diseases or NFkappaB mediated diseases.
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