INHIBITOREN UND SUBSTRATE FÜR THROMBIN

摘要

Peptides which act as inhibitors or substrates of thrombin are derived from the formula: Aa1 is wherein Ar1 and Ar2 are the same or different and are selected from naphthyl, thionaphthyl, indolyl and saturated groups corresponding to these, optionally substituted by up to three groups from C1-C3 alkyl and C1-C3 alkoxy, L1 and L2 are the same or different and are selected from CH2, CH2-CH2, O-CH2 and S-CH2, or Ar-L is H, diphenylmethyl, fluorenyl or saturated groups corresponding to these, provided that both Ar-L groups are not H; and Aa2 is or its C1-C3 alkyl substituted derivatives, wherein R8 is CH2, CH2-CH2, S-CH2, S-C(CH3)2 or CH2-CH2-CH2, provided that when Aa1 is naphthylalanine Y is C3-C9 alkyl or C5-C10 aryl or C5-C10 alkylaryl optionally substituted by up to three groups selected from hydroxy and C1-C4 alkoxy.