AMINE DERIVATIVE FIXED TO RESIN AND METHOD FOR SYNTHESIZING BETA-AMINOCARBONYL COMPOUND IN A SOLID PHASE

摘要

The invention provides a resin-immobilized imine represented by the following formula: P-Q-N-=CH-R in the formula, P represents the principal chain of a resin polymer; Q represents a substituted or unsubstituted hydrocarbon side chain or a substituted or unsubstituted hydrocarbon side chain with a heteroatom interposed therein; R represents a substituted or unsubstituted hydrocarbon group or heterocyclic group­ and a resin-immobilized beta -aminocarbonyl compound of the following formula: <CHEM> which can be released as beta -aminocarbonyl compound from the solid phase; and the invention also provide a resin-immobilized amine of the following formula: -P-Q1-O-Q2-NH2 Q1 and Q2 independently represent a hydrocarbon chain such as arylene, alkylenearylene or arylenealkylene­, which is essential for solid state synthesis; and the invention has enabled the solid state synthesis of beta -aminocarbonyl compound by the application of iminoaldol reaction.