| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject compound useful as synthetic intermediate for a medicine, etc., in a high yield by catalytically reducing a specific compound in a branched alcohol so as to subject the compound to a ring closure. SOLUTION: A compound of formula I [Ar is a (substituted) benzene; m and n are each 0 or 2] (e.g.α,α'-dicyano-o-xylene, etc.), is catalytically reduced and subjected to a ring closure in a branched alcohol (e.g. sec-butyl alcohol, etc.), of preferably 3-200 times as much as the compound preferably in the presence of hydrogen by using 0.01-300 wt.% based on the compound of formula I of a catalyst (e.g. Raney nickel, etc.), for 0.5-50 hours at 30-200 deg.C under 1-10 kg/cm2 to give the objective compound of formula II (e.g. 2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride, etc.). During or after the reaction of the catalytic reduction, preferably heating is carried out at 50-180 deg.C for 15 minutes to 20 hours.
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