| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel metal protease which comprises a metal protease containing a specific amino acid sequence and exhibiting protease activity, possesses high possibility as a target molecule for creating medicines and is useful in the search or the like of substances for promoting, decreasing and degenerating the protease activity. SOLUTION: This metal protease is a novel metal protease, which comprises an amino acid sequence containing No. 233 to No. 473 amino acids in the amino acid sequence represented by formula I, an amino acid sequence containing No. 234 to No. 478 amino acids in the amino acid sequence represented by formula II or an amino acid sequence containing No. 214 to No. 415 amino acids in the amino acid sequence represented by formula III and exhibits protease activity, or a novel metal protease exhibiting the activity similar to that of this metal protease, possesses high possibility as a target molecule for creating medicines, serves for the search or the like of substances for modifying protease activity and is capable of being utilized in the development or the like of therapeutic agents against cancer, arthritis, osteoarthritis or the like. This metal protease is obtained by screening out a human heart-derived cDNA library and integrating the resultant gene into an expression system to express. |
