| 摘要 |
<p>The use of antagonists of neurokirin receptors (NK-1; substance P receptors) in the treatment of adenocarcinomas, such antagonists having the following features: pA2⊃6.0 both in human and in murine tissues, etherocyclic non peptidergic structures, antiangiogenic effects experimentally demonstrated onto the genito-urinary tract tumors induced via orthotopic drafts of human tumoral cells either in the genito-urinary apparatus of either immunodeficient rats or mice, decrease of the tumoral mass on tumors of the genito-urinary tract induced by orthotopic drafts of tumoral cells onto tissues of the genito-urinary tract of either immunodeficient rats or mice. Preferred antagonists are FK 888, CP 96345, CP 99994, SR 140333, CGP 47899, RP 67580, MEN 11149, MEN 11467, GR 205171 or L - 703,606.</p> |
