GENE ENCODING PROMOTER DOMAIN OF TUMOR SUPPRESSOR GENE P51 AND USE THEREOF

摘要

A gene encoding the promoter domain of a protein p51 which is capable of inducing cell death; and a gene encoding the 5'-nontranslation domain of p51. These genes are useful in diagnosing and treating diseases typified by cancer caused by abnormal regulation of cell proliferation. Antisense DNAs and antisense RNAs of these genes; nucleic acid probes comprising the full sequences of these genes or parts thereof; a method for detecting the above genes or genes analogous thereto by using these nucleic acid probes; transformants having the above genes transferred thereinto; a method for screening a drug by using the same; and the like. These genes are also useful in diagnosing and treating diseases such as cancer.