Aminophosphonic acid derivatives, preparation and pharmaceutical compositions thereof

摘要

These aminophosphonates a-substituted by phenol groups have lipoprotein(a) lowering activity and are of the formula (I), where X1 and X2 each are H, OH, nitro, alkoxy or alkyl; and X3 is H or alkyl; or X3O and one of X1 and X2 may form a alkylene dioxy ring; R1 and R2 each are H or alkyl; B is CH2, CH2CH2 or CHCH, n is 0 or 1, Z is H or alkyl; Y1, Y2, Y3 and Y4 each are H alkyl, alkoxy, cyano, CF3, NO, OH, OHCH3, alkoxymethyl, amino, alkylamino, dialkylamino, halo, or any two adjacent Y moieties may form a alkyldiene or alkyidendioxy ring.