发明名称 C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
摘要 A chemic compound having the formula: wherein P1 is a hydroxyl protecting group, R1 is an alkyl group, an olefinic group, an aromatic group, Ph, PhCH2, an O-alkyl group, an O-olefinic group, an O-aromatic group, O-Ph, or O-CH2Ph, and wherein Z is an N-imido group. In particular, P1 may be selected from the group consisting of benzyl, benzyloxymethyl and benzoyl, and Z may be a heterocyclic N-imido group, preferably having 5 to 7 atoms in the ring and alternatively substituted with at least one electron withdrawing group, preferably selected from the group consisting of a chloro group, a fluoro group and a nitro group. In particular, it is contemplated that Z may be succinimido, phthalimido, 5-norbornene-2,3-dicarboxyimido, maleimido and substituted derivatives thereof.
申请公布号 US6143902(A) 申请公布日期 2000.11.07
申请号 US19990336962 申请日期 1999.06.21
申请人 NAPRO BIOTHERAPEUTICS, INC. 发明人 ZYGMUNT, JAN;MCCHESNEY, JAMES D.;CHANDER, MADHAVI C.
分类号 C07D207/40;C07D207/404;C07D207/44;C07D207/448;C07D209/48;C07D209/52;C07D209/76;C07D305/14;(IPC1-7):C07D207/40;C07D207/444;C07D209/56;C07D209/34 主分类号 C07D207/40
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