发明名称 |
Treatment of lfa-1 associated disorders with increasing doses of lfa-1 antagonist |
摘要 |
A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose. |
申请公布号 |
AU3759700(A) |
申请公布日期 |
2000.10.09 |
申请号 |
AU20000037597 |
申请日期 |
2000.03.17 |
申请人 |
GENENTECH INC.;XOMA TECHNOLOGY |
发明人 |
RUSSELL L. DEDRICK;MARVIN R. GARAVOY;SUSAN M. KRAMER;KAREN STARKO |
分类号 |
A61K45/00;A61K38/00;A61K39/395;A61P11/00;A61P11/06;A61P17/06;A61P25/28;A61P29/00;A61P37/06;A61P37/08;C07K16/28 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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