Substituted 4-aminopyrrole (3,2-d) pyrimidine derivatives that selectively bind to mammalian neuropeptide Y (NPY) receptors, and the use in treating feeding disorders and cardiovascular diseases

摘要

The use of the compound of Formula (I) for inhibiting or alleviating a pathological condition or physiological disorder in a mammalian subject characterised by or associated with neuropeptide Y. Wherein; R1 is methyl; R3 is phenyl; and R2 is selected from substituents consisting of Net2, HN(CH2)2Net2HN(CH2)3COOH, NHCH2CH2OH, HNPh, HN(CH2)2Ph, Formula (a), Formula (b), Formula (c), Formula (d), piperidinyl, morpholinyl, NHNH2, HNCH(CH3)2, HN(CH2)3CH3, HNCH2(CH3)2, HNCH(CH3)CH2(CH2)3CH3, HNCH2CH=CH2, Formula (e), HNCH2C6H5, or Formula (f).