发明名称 |
Formulation and system for intra-oral delivery of pharmaceutical agents |
摘要 |
A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption enhancer is adapted to modify the surface membrane such that absorption through the surface membrane is initiated or increased. The oral-absorption enhancer may comprise hydroxypropyl-beta-cyclodextrin and surfactants including benzalkonium chloride, benzethonium chloride, polysorbate 80, sodium lauryl sulfate, Brij surfactants, Tween and Pluronic surfactants. Also disclosed is a system for delivering the formulation including a mechanism for dispensing predetermined doses of the inventive formulation intra-orally as with an aerosol or spray pump or propellant device. |
申请公布号 |
AU2879100(A) |
申请公布日期 |
2000.08.29 |
申请号 |
AU20000028791 |
申请日期 |
2000.02.11 |
申请人 |
MQS, INC.;MILES A. LIBBEY III;RANDALL MCCOY;ROBERT O. WILLIAMS III |
发明人 |
RANDALL MCCOY;ROBERT O. WILLIAMS III;MILES A. LIBBEY III |
分类号 |
A61K9/00;A61K9/12;A61K9/50;A61K31/28;A61K31/4468;A61K38/25 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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