发明名称 |
INHIBITORS OF AMYLOID FORMATION |
摘要 |
Methods, compounds and compositions are disclosed for treating amyloidogenic diseases, and particularly prion diseases associated with conversion of protease sensitive PrP (PrP-sen) to protease resistant PrP (PrP-res), by administering therapeutically effective amounts of a tetrapyrrole. Particular disclosed tetrapyrroles having this activity include phthalocyanines, deuteroporphyrins, and meso-substituted porphines. Complexes of certain of the pyrroles with metals or metal ions produce compounds that are particularly effective in converting the conversion of PrP-sen to PrP-sen. The treatment of the present invention is particularly suited for preventing or inhibiting the progression of prion related diseases, such as transmissible spongiform encephalopathies.
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申请公布号 |
WO0009111(A9) |
申请公布日期 |
2000.07.27 |
申请号 |
WO1999US18297 |
申请日期 |
1999.08.11 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;CAUGHEY, WINSLOW, S.;CAUGHEY, BYRON |
发明人 |
CAUGHEY, WINSLOW, S.;CAUGHEY, BYRON |
分类号 |
A61K31/409;A61K31/555;(IPC1-7):A61K31/00 |
主分类号 |
A61K31/409 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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