| 摘要 |
<p>A knockout mouse unresponsive to peptideglycans, lipoproteins, lipopeptides, etc. which are useful in clarifying the role of each member of the TLR family (in particular, TLR2 and MyD88) in the signal transduction due to stimulation with bacterial cell components in vivo. This knockout mouse is prepared by the homologous recombination method with the use of a targeting vector constructed by substituting the whole gene fragment or a part thereof of the exon site containing the intracellular region of TLR2 or MyD88 gene by a plasmid having poly(A) signal and a marker gene.</p> |
