发明名称 |
Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11 |
摘要 |
Disclosed is a novel class of steroid compounds based on estradiol, and carrying an 11beta-substitution. Said substitution is a hydrocarbon group which may be linear or branched, provided that it comprises, as the longest chain on carbon atom no. 11 of the steroid skeleton, one single linear chain having a length of from 5 to 9 carbon atoms, wherein said chain may be saturated or unsaturated. The resulting compounds have a desirable mixed agonist/antagonist profile for estrogen receptor alpha and estrogen receptor beta. |
申请公布号 |
AU1967300(A) |
申请公布日期 |
2000.06.13 |
申请号 |
AU20000019673 |
申请日期 |
1999.11.18 |
申请人 |
AKZO NOBEL N.V. |
发明人 |
HUBERT JAN JOZEF LOOZEN;WILHELMUS GERARDUS EDUARDUS JOSEPH SCHOONEN |
分类号 |
A61K31/565;C07J1/00;C07J21/00 |
主分类号 |
A61K31/565 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|