| 发明名称 |
CoA-IT AND PAF INHIBITORS |
| 摘要 |
<p>Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.</p> |
| 申请公布号 |
EP0626969(B1) |
申请公布日期 |
2000.05.24 |
| 申请号 |
EP19930905896 |
申请日期 |
1993.02.11 |
| 申请人 |
SMITHKLINE BEECHAM CORPORATION;SMITHKLINE BEECHAM PLC;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
WINKLER, JAMES, DAVID;CHILTON, FLOYD, HAROLD, III;HICKEY, DEIRDRE MARY BERNADETTE |
| 分类号 |
A61K45/00;A61K31/40;A61K31/41;A61K31/415;A61K31/4152;A61K31/4166;A61K31/4192;A61K31/42;A61K31/421;A61K31/66;A61K31/675;A61P1/04;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P37/08;A61P43/00;C07D231/12;C07D233/54;C07D233/70;C07D233/84;C07D249/06;C07D263/32;C07D403/06;C07F9/06;C07F9/28;C07F9/6506;C12Q1/48;G01N33/50;(IPC1-7):C07F9/06;C07F9/650 |
主分类号 |
A61K45/00 |
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