METHOD FOR PRESERVING A HEMOGLOBIN BLOOD SUBSTITUTE

摘要

The present invention relates to a method for preserving a deoxygenated hemoglobin blood substitute and to a preserved deoxygenated blood substitute . The present invention is drawn to a method for preserving a deoxygenated hemoglobin blood substitute comprising maintaining the dexoygenated hemoglob in blood substitute in an oxygen barrier film primary package comprising a transparent laminate material, said film having an oxygen permeability of le ss than about 1.0 cc per 100 square inches (or about 0.155 cc per 100 square centimeters) per 24 hours per atmosphere at about 25~C and an external relative humidity of about 50%. The present invention is also drawn to a preserved deoxygenated hemoglobin blood substitute. Said preserved blood substitute comprises a deoxygenated hemoglobin blood substitute and an oxyge n barrier film primary package. Said oxygen barrier film primary package comprises a transparent laminated material, having an oxygen permeability of less than about 1.0 cc per 100 square inches (or about 0.155 cc per 100 squa re centimeters) per 24 hours per atmosphere at about 25~C and an external relative humidity of about 50%, within which the deoxygenated hemoglobin blo od substitute is sealed, thereby preserving the deoxygenated hemoglobin blood substitute in an environment that issubstantially free of oxygen.