EXTENDED RELEASE BUCCAL BIOADHESIVE TABLET

摘要

A bioadhesive tablet wherein the active ingredient may be protected from wat er or the surrounding environment, thereby protecting it from metabolism or fro m other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protect ed from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrate d (aqueous) fraction of the tablet is available for absorption (bioavailable).