Preparation of 4-cyano-4'-hydroxybiphenyl by Friedel-Craft alkylation reaction

摘要

The invention relates to a preparation process for 4-cyano-4'hydroxybiphenyl, said process comprising the protection of the hydroxy group of 4-phenyl-phenol, acylation of the protected 4-phenyl-phenol group by the Friedel Crafts reaction, conversion of the resulting ketone into an acid, amidification of the acid thus obtained, dehydration of the resulting amide and deprotection of the hydroxy group.