A synthesis of furan sulfonamide compounds useful in the synthesis of IL-1 inhibitors

摘要

An efficent synthesis of furan sulfonamide compounds of formula <CHEM> comprising reacting a compound of formula II with a Grignard reagent in a reaction inert solvent, wherein R' is (C1-C6)alkyl. The compound of formula II is prepared by reacting a compound of formula III with a compound of formula IV wherein R' is (C1-C6)alkyl with a chorinating reagent and an acid scaverger in an inert solvent. The invention also includes a novel compound of the formula <CHEM> wherein R' is (C1-C6)alkyl and Q is halo, hydroxy or amino.CHEM