发明名称 |
Gro genes |
摘要 |
Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably monocytes adhered to plastic; or peripheral blood leukocytes induced with calcium ionophore and mezerin. The two cytokines are Gro beta and gamma , and their cDNA and amino acid sequences are disclosed. The expression of the genes in various cells is presented. Assay and diagnostic utilities using the cytokines; recombinant materials and procedures; purification procedures; and monoclonal antibodies to the cytokines are also shown.
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申请公布号 |
US6001605(A) |
申请公布日期 |
1999.12.14 |
申请号 |
US19940190249 |
申请日期 |
1994.01.31 |
申请人 |
CHIRON CORPORATION;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
HASKILL, JOHN STEPHEN;RALPH, PETER;NITECKI, DANUTE E.;MARTIN, GEORGE |
分类号 |
A61K38/00;A61K49/00;A61K51/08;C07K14/00;C07K14/52;C07K16/00;C07K16/24;C12N1/21;C12N15/09;C12N15/19;C12P21/02;C12P21/08;C12Q1/68;C12R1/19;G01N33/53;(IPC1-7):C12N1/21;C12N5/10;C12N15/63 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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