发明名称 |
ENALAPRIL MALEATE-BASE SOLID MEDICINAL FORM |
摘要 |
FIELD: medicine, pharmacy. SUBSTANCE: enalapril maleate-base solid medicinal form is made as pressed granules (size is 0.75 mm) powdered with a mixture of starch and magnesium or calcium stearate. Granules have a mixture of enalapril maleate on matrix made of polyvinylpyrrolidone with starch and lactose. The form has enalapril maleate at the therapeutically effective amount, lactose 48-52 mas. p.; starch 33-42 mas. p.; polyvinyl-pyrrolidone 1-2 mas. p.; calcium or magnesium stearate 1 mas. p. being 17-60% of starch mass can be as component of granules and 40-83% - as component of powdering mixture. The preferable content of enalapril maleate - 10 mg. The form exhibits good decomposition after its intake by patient and does not enter harmful and inert substances in the body as a result of balanced composition of components. The proposed medicinal form can be used for treatment of patients with arterial hypertension and cardiac failure. EFFECT: enhanced effectiveness of the form, improved quality and properties. 3 cl, 4 ex
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申请公布号 |
RU2140261(C1) |
申请公布日期 |
1999.10.27 |
申请号 |
RU19970105462 |
申请日期 |
1997.04.03 |
申请人 |
OTKRYTOE AKTSIONERNOE OBSHCHESTVO "AJ SI EHN LEKSR;OTKRYTOE AKTSIONERNOE OBSHCHES |
发明人 |
PROKHODA E.F.;BULATOV A.E.;SHTEJNGART MARK VOL'FOVICH;SKAKUN NONA NIKOLAEVNA;GONCHAROV NIKOLAJ IVANOVICH;DIKHTJAREV SERGEJ IVANOVICH;CHAJKA LEONID ALEKSANDROVICH |
分类号 |
A61K31/40;A61K9/20;A61K47/26;A61K47/32;A61K47/36;A61P9/04;A61P9/12;(IPC1-7):A61K9/20 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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