| 摘要 |
This disclosure provides a method of selecting one or more peptides or groups of peptide or protein bound to a carrier (for example, as part of peptide-expressing bacteriophage, from a peptide or protein expressing phage library or other ligand bound to an immunogenic carrier), that recognize and bind to epitopes exposed on one target class of cells or tissue only, and the application of the selected group of peptides or proteins or ligand and their carriers as markers to identify the desired target cells or target tissue in situ. Desirably, the immune system has been primed to recognize and respond to the carrier of the peptide or protein, so that a target cell/carrier/antibody complex is formed. Alternatively, the immune response to the carrier can be generated during treatment. By interposing the carrier between the and the responding antibody, the immune system's tolerance to the target is bypassed. Thus, the immune system can be made to target any desired cell within the body for elimination by decorating that target cell or target tissue with a carrier bearing a peptide which specifically binds to the target cell.
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