| 发明名称 |
Therapeutic Quassinoid preparations with antineoplastic, antiviral, and herbistatic activity |
| 摘要 |
PCT No. PCT/US95/14321 Sec. 371 Date May 1, 1997 Sec. 102(e) Date May 1, 1997 PCT Filed Nov. 3, 1995 PCT Pub. No. WO96/14065 PCT Pub. Date May 17, 1996The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
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| 申请公布号 |
US5965493(A) |
申请公布日期 |
1999.10.12 |
| 申请号 |
US19970836805 |
申请日期 |
1997.05.01 |
| 申请人 |
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC.;THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY;PURDUE RESEACH FOUNDATION |
发明人 |
GRIECO, PAUL A.;MORRE, D. JAMES;CORBETT, THOMAS H.;VALERIOTE, FREDERICK A. |
| 分类号 |
C07D493/04;A01N43/16;A01N43/90;A01N65/00;A61K31/35;A61K31/365;A61K31/366;A61P31/12;A61P35/00;C07D493/08;C07D493/10;(IPC1-7):A01N43/12 |
主分类号 |
C07D493/04 |
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