PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPASE)

摘要

Compounds of formula (A) are disclosed wherein R1 is aralkyl or cycloalkyl; R2 is cycloalkylmethyl, alkyl, or aralkyl; R3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; R4 is hydrogen, alkyl, substituted phenyls (including 1-alkyl-4-carboxy-substituted phenyls), alkyl carboxylic acids; R5 is hydrogen or R1 and R5 taken together forming a tetrahydroisoquinoline ring or a piperidine ring. These compounds exhibit inhibitory action against fructose-1,6-bisphosphatase (FBPase) and are indicating in the treatment or management of Type II diabetes.